Dissertation / PhD Thesis/Book

PreJuSER-50362

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Kernchemische Studien zur Entwicklung neuerer Produktionsverfahren für die therapierelevanten Radionuklide 140Nd, 192Ir, 191Pt, 193mPt und 195mPt

Hilgers, K. (Corresponding author)FZJ*

2005
Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag Jülich

Please use a persistent id in citations: http://hdl.handle.net/2128/514

Report No.: Juel-4197

Abstract: New production routes for the therapeutically useful radionuclides $^{140]$Nd, $^{192}$Ir, $^{191}$Pt, $^{193m}$Pt and $^{195m}$Pt were investigated. Cross section data were measured using the stacked-foil technique and compared with theoretical calculations. A production method for the platinum nuclides was developed. The $^{141}$Pr(p,2n)$^{140}$Nd and $^{nat}$Ce($^{3}$He,xn)$^{140}$Nd reactions were investigated for production of $^{140}$Nd. Cross section data of nuclear reactions leading to the side products $^{141}$Nd, $^{139}$Nd and $^{139}$Ce could also be achieved. The experimental data were compared with theoretical calculations using the code ALICE-IPPE. A comparison of the calculated thick target yields showed that the $^{141}$Pr(p,2n)$^{140}$Nd reaction gives a higher yield. The $^{192}$Os(p,n)$^{192}$Ir reaction was examined in the context of the production of $^{192}$Ir. Cross section data were determined and compared with theoretical calculations using the codes ALICE-IPPE und EMPIRE II. The yield of this reaction was compared with the yield of the reactor production of this nuclide. The reactor production seems to be more suitable because of a higher purity and yield. Cross section data were measured for the $^{192}$Os($\alpha$,n)$^{195m}$Pt, $^{192}$Os($\alpha$,3n)$^{193m}$Pt and $^{192}$Os($^{3}$He,4n)$^{191}$Pt reactions. The activity of $^{193m}$Pt und $^{195m}$Pt was determined by X-ray spectroscopy after a chemical separation procedure. The ALICE-IPPE code was found to be inappropriate to reproduce the experimental values. The calculated yields were compared with the yields of other reactions, especially the reactor production of $^{195m}$Pt. The yield of the $^{192}$Os($\alpha$,n)$^{195m}$Pt reaction is lower compared to the yield of the reactor production, but offers lower target costs and higher specific activity. A production method for $^{193m}$Pt und $^{195m}$Pt was developed. Batch yields of 0.9 MBq $^{195m}$Pt (specific activity of about 150 GBq/g Pt) and 8.7 MBq $^{193m}$Pt (ca. 3 TBq/g Pt) could be achieved. The experimental yields were compared with the calculated yields. The agreement between these two data sets was satisfactory.

Note: Record converted from VDB: 12.11.2012
Note: Köln, Univ., Diss., 2005

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Contributing Institute(s):

1. Institut für Nuklearchemie (INC)

Research Program(s):

1. Neurowissenschaften (L01)

Appears in the scientific report 2005

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Database coverage:

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